[sf-perl] Genentech is hiring [more].

Fred Moyer fred at redhotpenguin.com
Fri Apr 9 14:28:06 PDT 2010

Hi George,

While we really appreciate you thinking of the list for your
prospects, in the future please use the [job] tag in the subject for
all job postings to the list, per the previous discussion here:



On Fri, Apr 9, 2010 at 2:00 PM, George Hartzell <hartzell at alerce.com> wrote:
> We're hiring.  You want to do Bioinformatics and Computational Biology
> at a great company in South San Francisco, CA.  Sounds like a good
> match!  There are both full-time and temporary openings.
> I'm looking for someone who's sharp and who enjoys computers, biology,
> and technology; someone who gets excited about picking up new tools
> but who also has a sense of responsibility and restraint.  You've
> worked with a variety of computer languages over your career and look
> forward to learning more in the future; you can build up a system from
> a blank hard disk and an OS cd if necessary but are just as happy if
> someone else takes care of it; you like your projects to build and
> install themselves because let's face it, who wants to do that stuff
> by hand.  It sounds like we're made for each other.
> I'm looking for someone who's familiar with several modern tool sets
> and has used them to deliver applications that really solve a problem
> and that aren't a bear to extend and maintain.  Modern Perl
> complemented with C is my first choice these days, supplemented with R
> and (when necessary) anything from the rest of the programming
> language bestiary.  There's a fair amount of Java flying around here
> too so some familiarity with it and the JVM world would be great.
> Relational databases are part of the picture: Oracle for the big
> stuff; SQLite, PostgreSQL, and MySQL in supporting roles.  I generally
> interact with them via ORM's, lately it's been Rose::DB::Object on the
> Perl side though I've been convinced to take another look at
> DBIx::Class.  Most of my web apps use CGI::Application, as fastcgi's,
> mod_perl, or simple CGI scripts, but (as with ORM's) I may take
> another look at Catalyst.  If most of those words ring a bell, we
> should talk.
> Does it sound like you'd be happy working here?  Well, you're still
> reading....  Great!
> Strong candidates will have an understanding of basic bioinformatics
> concepts and the ability to pick up new biology and computer science
> concepts as necessary.  You could probably leverage a strong
> non-biological science background complemented with the right software
> engineering experience and make an argument that you're a good fit.
> At the junior end of the spectrum I'd expect a bachelor's degree + 3
> years of experience, at the upper end would a masters + 5 years (or a
> PhD interested in moving towards the production side of the house).
> When you get to an interview, you might get questions like:
> - What's the difference between Smith-Waterman, blast, sim4, gmap,
>  and/or bowtie alignment algorithms or tools? Which would you use
>  when, and why?
> - Why is Moose better than Class::Accessor? (yes, it's Perl centered,
>  but it could spin out into any language [e.g. why is Java better
>  than Perl?]).  What's a MOP? Who cares?
> - How do you roll out a release of your software?  What's automated,
>  and how?  What's not, and why?
> - CVS, subversion, git, mercurial. You've already picked one, of
>  course.  Which one? Why? Why not?
> - XML or JSON or YAML.  Pick one for moving data back and forth in an
>  Ajax based interface.  Why? Would it also work well in other
>  contexts?
> - How would you store information about positional features on a
>  genome so that you could get fast random access? How would your
>  solution tie into a larger data context?
> Genentech's a great place to work: solid salaries, great benefits,
> great Bay Area location.  We're open source friendly and with the
> arrival of Robert Gentleman (our new Director, of Bioconductor/R fame)
> are becoming even more so.
> Send a cover letter and CV to me at georgewh at gene.com.  Bonus points
> if it's easy to unpack and read (pdf would be great...).  Demerits if
> you use an obscure archive format to deliver Wordstar files.  Double
> demerits if you don't follow directions and reply to this account....
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